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Isopropanol → HCID 178491933、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | 4-Methoxyphenyl isothiocyanate | HCID 75293 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | Ethanone, 2-amino-1-phenyl-, hydrochloride (1:1) | HCID 2723597 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | HCID 178491933 | HCID 178491933 | 90% |
反応手順
A mixture of 17.5 parts of 2-amino-1-phenylethanone hydrochloride, 16.5 parts of 1-isothiocyanato-4-methoxybenzene, 10 parts of sodium hydrogen carbonate and 200 parts of 2-propanol is stirred first for 30 minutes at room temperature and further for 2 hours at reflux temperature. The reaction mixture is poured onto 500 parts of water. The product is filtered off and stirred and refluxed for 1 hour with 240 parts of hydrochloric acid solution 10%. After cooling, the product is filtered off, washed with water and 2-propanol, and dried, yielding 25.3 parts (90%) of 1-(4-methoxyphenyl)-5-phenyl-1H-imidazole-2-thiol; m.p. 267.4° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04229460 |
| 出典データセット | uspto-grants-1980_10 |
| ORD ID | ord-3f343a572d8f41b5b1967db150308d46 |
| 出典メモ | uspto-grants-1980_10 |