反应详情

2,3-Dihydrobenzofuran (4.8 g, 40 mmole) is stirred with 9.0 g (40 mmole) of α-hydroxy-hippuric acid in 200 ml of 10% H2SO4 -90% acetic acid mixture. The reaction is run at room temperature for 0.5 hour. After the half-hour, the reaction mixture is poured into 500 ml of water. The aqueous solution is extracted with ethyl acetate (4×100 ml). The ethyl acetate extracts are dried over magnesium sulfate and then evaporated to give α-benzamido(2,3-dihydro-5-benzofuranyl)acetic acid. Recrystallization of the crude benzamido compound from hexanemethylene chloride gives 11.56 g (94% yield).

1. extractionThe aqueous solution is extracted with ethyl acetate (4×100 ml)
2. dry with materialThe ethyl acetate extracts are dried over magnesium sulfate
3. customevaporated