HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 131711927, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Glycine | HCID 750 | — |
| Reactant | L-Alanine | HCID 5950 | — |
| Reactant | L-Aspartic Acid | HCID 5960 | — |
| Reactant | L-Lysine | HCID 5962 | — |
| Reactant | L-Leucine | HCID 6106 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | L-Glutamic Acid | HCID 33032 | — |
| Reactant | HCID 131711928 | HCID 131711928 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 131711927 | HCID 131711927 | — |
Reaction Steps
450 mg of pGlu-Ala-Lys(Boc)-Ser-Gln-Gly-(D)-Leu-Ser-Asn-OBut is treated with 5 ml of trifluoroacetic acid at room temperature for 40 minutes and the reaction product is purified as in Example 1-(VIII). Yield 260 mg (58%); [α]D23 -40.0° (c=0.31, H2O); Rf4 (Avicel)=0.23, amino acid analysis (hydrolyzed with HCl); Lys, 0.95(1); Asp, 0.92(1); Ser, 1.79(2); Glu, 2.05(2); Gly, 1.01(1); Ala, 1.05(1); Leu, 1.05(1); average recovery 81%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04229438 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-88d09238ae384febab6b63b24a820783 |
| Source note | uspto-grants-1980_10 |