Benzene → HCID 12905317, compound

Participants

Reaction Steps

2.1 grams (0.018 mole) of methylaminoacetaldehyde dimethylacetal was added to a 50 ml. benzene solution containing 5.2 grams (0.018 mole) of the 5-(1-(2-nitrophenoxy) ethyl)-1,3,4-thiadiazol-2-yl isocyanate dimer (prepared above) and the resulting solution was refluxed for 15 minutes to form a yellow solution. Hexane (100 ml.) was added and the resulting oil was allowed to stand for 72 hours and topped with a roto-vac at 70 degrees Centigrade to yield 7.2 grams of a red-orange oil of 3-[5-(1-(2-nitrophenoxy ethyl)-1,3,4-thiadiazol-2-yl]-1-methyl-1-(2,2-dimethoxyethyl)urea.

Provenance & Evidence