huagongshe.com
HRID904060

反应详情

EQUATION

反应方程式

HRID 904060 的结构方程式

REACTANTS

反应物

4
结构：[K]
HCID5462222

Potassium

K

结构：CC1(C)S[C@@H]2C(NC(=O)COc3ccccc3)C(=O)N2C1C(=O)O
HCID12373893

未命名化合物

结构：CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)[O-].[K+]
HCID23664709

Penicillin G potassium

C16H17KN2O4S

结构：O=S([O-])OO.[K+]
HCID23707502

未命名化合物

PRODUCTS

生成物

1
结构：CC1(C)[C@H](C(=O)O)N2C(=O)[C@@H](NC(=O)Cc3ccccc3)[C@H]2S1=O
HCID107496

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- (2S,5R,6R)-, 4-oxide

C16H18N2O5S

收率 98%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

2 次

PROCEDURE

实验过程

To 50 ml. of water were added 19.4 grams (50 millimoles) of the potassium salt of 6-phenoxyacetamido-2,2-dimethylpenam-3-carboxylic acid. A solution of 20 grams (65 millimoles active oxygen) of Oxone® in 100 ml. water was added dropwise to the penicillin solution over a 45 minute period. The mixture was stirred for about 10 minutes at room temperature. The resulting precipitate was collected by filtration and washed with 25 ml. of water. The precipitate was dried in vacuo at 40° C. overnight to afford 17.95 grams (98%) of the corresponding penicillin sulfoxide. Analysis of the product by high performance liquid chromatography (HPLC) indicated the presence of 23.0% of the α-isomer and 74.1% of the β-isomer.

WORKUP

后处理

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with 25 ml
  3. customThe precipitate was dried in vacuo at 40° C. overnight