Sodium borohydride → HCID 12805918, compound

Participants

Reaction Steps

16 G. of 5,5-dimethyl-2-phenyl-4-(p-dimethylaminophenyl)-1-pyrroline are dissolved in 300 ml. of absolute ethanol and treated with 16 g. of sodium borohydride. The solution is stirred under nitrogen at room temperature for 14 hours. It is subsequently evaporated to dryness under reduced pressure and the residue suspended in water by intensive stirring. The non-dissolved constituent is filtered off, dried and recrystallized, first from n-hexane and then from diisopropyl ether. There is obtained cis-3-(p-dimethylaminophenyl)-2,2-dimethyl-5-phenyl-pyrrolidine, having a melting point of 117°-118° C.

Provenance & Evidence