3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid → 3-[5-Amino-6-[1-(2-chloro-3,6-difluorophenyl)ethoxy]pyrazin-2-yl]benzoic acid

HRID 90407Notes

Reaction equation

HRID 90407 reaction equation
[Br:1][c:2]1[n:3][c:4]([O:9][CH:10]([CH3:11])[c:12]2[c:13]([Cl:20])[c:14]([F:19])[cH:15][cH:16][c:17]2[F:18])[c:5]([NH2:8])[n:6][cH:7]1.[CH3:21][C:22]1([CH3:23])[C:24]([CH3:25])([CH3:26])[O:27][B:28]([c:29]2[cH:30][c:31]([C:32](=[O:33])[OH:34])[cH:35][cH:36][cH:37]2)[O:38]1>>[c:2]1(-[c:29]2[cH:30][c:31]([C:32](=[O:33])[OH:34])[cH:35][cH:36][cH:37]2)[n:3][c:4]([O:9][CH:10]([CH3:11])[c:12]2[c:13]([Cl:20])[c:14]([F:19])[cH:15][cH:16][c:17]2[F:18])[c:5]([NH2:8])[n:6][cH:7]1

Participants

3

Reactant 2

HCID 27346533-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acidHCID 211114825-Bromo-3-[1-(2-chloro-3,6-difluoro-phenyl)-ethoxy]-pyrazin-2-ylamine

Product 1

HCID 211111113-[5-Amino-6-[1-(2-chloro-3,6-difluorophenyl)ethoxy]pyrazin-2-yl]benzoic acid

Sources & evidence

ORD record
ord-5cff3cf6728f4f9c8eaea3f2167ab9d7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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