Acetic Anhydride → 3-[3-[4-(Acetyloxy)phenyl]propyl]glutaric anhydride

HRID 904078Notes

Reaction equation

[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH:11]([CH2:16][C:17]([OH:19])=[O:18])[CH2:12][C:13]([OH:15])=O)=[CH:4][CH:3]=1.[C:20](OC(=O)C)(=[O:22])[CH3:21]>>[C:20]([O:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][CH2:10][CH:11]2[CH2:12][C:13](=[O:15])[O:18][C:17](=[O:19])[CH2:16]2)=[CH:6][CH:7]=1)(=[O:22])[CH3:21]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 20528822HCID 20528822, compound

Product 1

HCID 540038443-[3-[4-(Acetyloxy)phenyl]propyl]glutaric anhydride

Procedure

3-[3-(4-Hydroxyphenyl)propyl]glutaric acid (533 mg) is reacted with acetic anhydride as described in Example 1C to afford 3-[3-[4-(acetyloxy)phenyl]propyl]glutaric anhydride, melting point 55°-57° C.

Sources & evidence

ORD record: ord-42583b4438944715901eb9f84440a972
Source dataset: uspto-grants-1980_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04230621

Reaction notes

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