HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Amino-4'-(hexafluoro-2-hydroxy-2-propyl)benzenesulfonanilide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Acetamido-4'-(hexafluoro-2-hydroxy-2-propyl)benzenesulfonanilide | HCID 23333497 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 4-Amino-4'-(hexafluoro-2-hydroxy-2-propyl)benzenesulfonanilide | HCID 23333525 | — |
Reaction Steps
Reflux for 3 hours a solution of 2.3 g (5 mmole) 4-acetamido-4'-(hexafluoro-2-hydroxy-2-propyl)benzenesulfonanilide in 30 ml EtOH and 4 g 50% NaOH. Pour onto water, acidify with concentrated HCl, extract with Et2O, dry and concentrate. Recrystallize from CHCl3 -Et2O to give the product; m.p. 160°-161° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04230635 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-c4a060340bf8461c85b463c30c7d71da |
| Source note | uspto-grants-1980_10 |