Methanesulfonyl chloride → HCID 54471744, compound

Participants

Reaction Steps

To 3.23 g (10 mmole) 4-(hexafluoro-2-hydroxy-2-propyl)-2-methyl-1-naphthylamine in 25 ml pyridine add 1.25 g (11 mmole) methanesulfonyl chloride. After 2 hours, pour onto water and extract with Et2O. Wash with 1N HCl, and then extract with 1N NaOH. Acidify with concentrated HCl, extract with Et2O, dry and concentrate. Recrystallize from Et2O-hexane to obtain the product; m.p. 174° C.

Provenance & Evidence