HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 23333523, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | HCID 54197899 | HCID 54197899 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 23333523 | HCID 23333523 | — |
Reaction Steps
Add 2.50 g (22 mmole) of methanesulfonyl chloride dropwise to 4.57 g (15 mmole) of methyl 5-(hexafluoro-2-hydroxy-2-propyl)anthranilate in 25 ml of pyridine and allow to stand overnight. Pour the reaction into H2O and extract with Et2O. Wash the Et2O with 1N HCl and extract with 1N NaOH. Acidify the NaOH and extract with Et2O. Dry, concentrate and recrystallize from Et2O-hexane to obtain 4'-(hexafluoro-2-hydroxy-2-propyl)-2'-(methoxycarbonyl)methanesulfonanilide; m.p. 147°-148° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04230635 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-ed96c9d34fba4ae3be75ef62096dcdee |
| Source note | uspto-grants-1980_10 |