Water → HCID 23333501, compound

Participants

Reaction Steps

Add 2.5 g (22 mmole) of methanesulfonyl chloride dropwise to 5.5 g (15 mmole) of 2-bromo-4-(hexafluoro-2-hydroxy-2-propyl)-6-methoxyaniline in 30 ml of pyridine below 10° C. Allow to stand overnight. Pour into H2O and decant. Dissolve the oil in Et2O, wash with 1N HCl and extract with 1N NaOH. Acidify the NaOH with HCl and extract with Et2O. Dry and concentrate. Chromatograph the oil on silica gel, eluting with CHCl3. Recrystallize from CH2Cl2 to obtain 2'-bromo-4'-(hexafluoro-2-hydroxy-2-propyl)-6'-methoxymethanesulfonanilide; m.p. 38°-41° C.

Provenance & Evidence