Ethanolamine → HCID 20565977, compound

HRID 904106Notes

Reaction equation

HRID 904106 reaction equation
[CH:1]([C:5]([CH3:13])([CH:9]([CH3:12])[CH2:10][CH3:11])[C:6](Cl)=[O:7])([CH2:3][CH3:4])[CH3:2].[CH2:14]([CH2:16][NH2:17])[OH:15]>C1C=CC=CC=1>[OH:15][CH2:14][CH2:16][NH:17][C:6](=[O:7])[C:5]([CH:9]([CH2:10][CH3:11])[CH3:12])([CH3:13])[CH:1]([CH3:2])[CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 20565976HCID 20565976, compound

Product 1

HCID 20565977HCID 20565977, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

A solution of 2-sec-butyl-2,3-dimethylpentanoyl chloride (2.0 g) in benzene (10 ml) was added to a stirred solution of ethanolamine (2.0 g) in benzene (100 ml). After 16 hours the benzene solution was washed with dilute hydrochloric acid and water, dried (MgSO4) and concentrated to give a pale yellow syrup. Distillation of this syrup gave N-(2-hydroxyethyl)-2-sec-butyl-2,3-dimethylpentanamide bp. 125°-130°/0.03 mm which slowly solidified on standing.

Workup

  1. washAfter 16 hours the benzene solution was washed with dilute hydrochloric acid and water
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated
  4. customto give a pale yellow syrup
  5. distillationDistillation of this syrup

Sources & evidence

ORD record
ord-b116bdf82f4c4b20a271a4706d9c1a3a
Source dataset
uspto-grants-1980_10
Patent number
US04230688

Reaction notes

Loading…