HCID 178454169, compound → HCID 178419078, compound

Participants

Reaction Steps

While maintaining the nitrogen gas atmosphere, 3 fold molar excess of the benzyl ester of Boc-L-Histidine (Vega, supra.) dissolved in 15 ml. of methylene chloride is added to the residue of Step (H) above. The resulting mixture is shaken and after about 10 minutes, 3 fold molar excess of N,N-dicyclohexylcarbodiimide in 15-20 ml. of methylene chloride is added with stirring. The resulting mixture is shaken at room temperature for 4.5 to 5 hours. At the end of this period, the reaction mixture is filtered and the residue washed and dried.

Provenance & Evidence