DL-Serine → HCID 12942449, compound

Participants

Reaction Conditions

Reaction Steps

DL-Serine (5.0 g) was dissolved in water (25 ml) containing sodium hydroxide (23.8 ml, 2N) and the mixture cooled to 0° C., stirred and n-butyl isocyanate (9.4 g) added. The mixture was stirred at 0° C. for 2 hours then allowed to rise to room temperature overnight, filtered and the filtrate acidified with concentrated hydrochloric acid (50 ml) and heated on a steam-bath for 2 hours. The mixture was cooled and extracted with ether (3×100 ml). Removal of the ether gave an oil which rapidly crystallised and the title product recrystallised from carbon tetrachloride as small cubes, m.p. 93° C. Yield 5.1 g=57%.

Provenance & Evidence