反应详情

A mixture of N-methyl-N-(2-cyanobenzyl)-4-ethoxycarbonylmethylaniline (6 g) and polyphosphoric acid (60 g) was stirred for 2 hours with heating at 130°-140° C. After the reaction, the reaction mixture was poured into iced water (500 ml) to precipitate crystals. The crystals were collected, washed in water, and then vacuum-dried over diphosphorus pentoxide to obtain the desired compound (2.5 g) as yellow prismatic crystals.

1. temperaturewith heating at 130°-140° C
2. customAfter the reaction
3. customto precipitate crystals
4. customThe crystals were collected
5. washwashed in water
6. dry with materialvacuum-dried over diphosphorus pentoxide