Water → 4-(5-Chloropyridin-2-yl)-4-hydroxycyclohexanecarboxylic acid ethyl ester

HRID 90419Notes

Reaction equation

HRID 90419 reaction equation
[Br:6][c:7]1[n:8][cH:9][c:10]([Cl:13])[cH:11][cH:12]1.[CH2:14]([CH3:15])[O:16][C:17](=[O:18])[CH:19]1[CH2:20][CH2:21][C:22](=[O:25])[CH2:23][CH2:24]1.[CH3:27][CH2:28][O:29][CH2:30][CH3:31].[Li:1][CH2:2][CH2:3][CH2:4][CH3:5].[OH2:26]>>[c:7]1([C:22]2([OH:25])[CH2:21][CH2:20][CH:19]([C:17]([O:16][CH2:14][CH3:15])=[O:18])[CH2:24][CH2:23]2)[n:8][cH:9][c:10]([Cl:13])[cH:11][cH:12]1

Participants

6

Reactant 5

HCID 962WaterHCID 3283Diethyl EtherHCID 317638Ethyl 4-oxocyclohexanecarboxylateHCID 8170982-Bromo-5-chloropyridineHCID 178418339Butyllithium

Product 1

HCID 684258024-(5-Chloropyridin-2-yl)-4-hydroxycyclohexanecarboxylic acid ethyl ester

Sources & evidence

ORD record
ord-d344a89610bb47dab423e4ad6668ec0d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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