Water → HCID 23333588, compound

Participants

Reaction Steps

A mixed liquid of methyl 5,6-dihydro-5-ethyl-11-oxodibenz[b,e]azepine-2-acetate (0.9 g), sodium hydroxide (2 g), methanol (50 ml) and water (20 ml) was heated under refluxing for 2 hours. After the reaction, methanol was distilled off, and the remaining aqueous layer was washed with ether. The aqueous layer was treated with activated carbon powder, and a 5% sulfuric acid aqueous solution was added while cooling the layer with ice. The precipitated crystals were collected by filtration, washed in water, and vacuum-dried over P2O5 to obtain 5,6-dihydro-5-ethyl-11-oxodibenz[b,e]azepine-2-acetic acid (0.7 g), the desired compound, as yellow powdery crystals.

Provenance & Evidence