Methanol → 5H-Dibenz(b,e)azepine-2-acetic acid, 6,11-dihydro-11-oxo-

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Reaction Steps

A mixture of ethyl 5,6-dihydro-11-oxodibenz[b,e]azepine-2-acetate (0.333 g), methanol (20 ml) sodium hydroxide (1 g) and water (20 ml) was heated under refluxing for 3 hours. After removal of the solvent by distillation, water was added to the mixture, and then, 5% sulfuric acid was added. The precipitated crystals were collected by filtration, washed in water, and dried to obtain 5,6-dihydro-11-oxodibenz[b,e]azepine-2-acetic acid (0.206 g). m.p.: 135°-145° C.

Provenance & Evidence