Cyanogen Bromide → HCID 86737291, compound

Participants

Reaction Steps

A rapidly stirred mixture of 8β,17-dimethyl-3-methoxymorphinan-6-one (free base; prepared in Part A) in chloroform (1.0 g/10 ml) containing 1.5 g finely powdered dry K2CO3 was treated dropwise with a solution of cyanogen bromide in chloroform (1.2 equivalents; 1.0 g/20 ml). The mixture was stirred rapidly for 30 minutes and then heated at reflux for an additional two hours. The solution was cooled, filtered, evaporated to dryness and azeotroped with alcohol. The crystalline, mp. 202°-205° C., product was obtained in 81% yield and was used without further pruification.

Provenance & Evidence