Cyanogen Bromide → HCID 86737292, compound

HRID 904211Notes

Reaction equation

HRID 904211 reaction equation
[CH2:1]([C@@H:3]1[C@@H:16]2[C@:7]3([CH2:19][CH2:18][N:17]([CH3:20])[C@@H:15]2[CH2:14][C:13]2[CH:12]=[CH:11][C:10]([O:21][CH3:22])=[CH:9][C:8]3=2)[CH2:6][C:5](=[O:23])[CH2:4]1)[CH3:2].[N:24]#CBr>>[C:20]([N:17]1[CH2:18][CH2:19][C@@:7]23[C:8]4[CH:9]=[C:10]([O:21][CH3:22])[CH:11]=[CH:12][C:13]=4[CH2:14][C@@H:15]1[C@@H:16]2[C@@H:3]([CH2:1][CH3:2])[CH2:4][C:5](=[O:23])[CH2:6]3)#[N:24]

Participants

3

Reactant 2

HCID 10476Cyanogen BromideHCID 53893668HCID 53893668, compound

Product 1

HCID 86737292HCID 86737292, compoundYield 73%

Procedure

To a rapidly stirred solution of 8β-ethyl-3-methoxy-17-methylmorphinan-6-one (prepared in Part A) was added cyanogen bromide as in Example 1B. The product, mp. 141°-145° C., was obtained in 73% yield.

Workup

  1. customThe product, mp. 141°-145° C., was obtained in 73% yield

Sources & evidence

ORD record
ord-20a18dc29b284c369d110fd57c6c9db7
Source dataset
uspto-grants-1980_10
Patent number
US04230712

Reaction notes

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