Cyanogen Bromide → HCID 86737293, compound

HRID 904213Notes

Reaction equation

HRID 904213 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:7][C@H:8]3[N:19]([CH3:20])[CH2:18][CH2:17][C@@:14]4([C:15]=2[CH:16]=1)[C@H:9]3[C@@H:10]([CH2:22][CH2:23][CH3:24])[CH2:11][C:12](=[O:21])[CH2:13]4.[N:25]#CBr>>[C:20]([N:19]1[CH2:18][CH2:17][C@@:14]23[C:15]4[CH:16]=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][C:6]=4[CH2:7][C@@H:8]1[C@@H:9]2[C@@H:10]([CH2:22][CH2:23][CH3:24])[CH2:11][C:12](=[O:21])[CH2:13]3)#[N:25]

Participants

3

Reactant 2

HCID 10476Cyanogen BromideHCID 70586552HCID 70586552, compound

Product 1

HCID 86737293HCID 86737293, compoundYield 97%

Procedure

To a rapidly stirred solution of 3-methoxy-17-methyl-8β-n-propylmorphinan-6-one (prepared in Part A) was added cyanogen bromide as in Example 1B. The product was obtained as a syrup, 97% yield, and was used without further purification.

Workup

  1. customThe product was obtained as a syrup, 97% yield
  2. customwas used without further purification

Sources & evidence

ORD record
ord-5ce07e4532df4dd591393a89fc51ff8e
Source dataset
uspto-grants-1980_10
Patent number
US04230712

Reaction notes

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