Cyanogen Bromide → HCID 86737294, compound

Participants

Reaction Steps

To a mixture of 9 (11.30 g, 34.5 mmol) and potassium carbonate (7.15 g, 51.8 mmol) in chloroform (75 ml) was added dropwise cyanogen bromide (4.45 g, 42.0 mmol) in chloroform. The reaction mixture was refluxed for 2 hours and processed as above to give 10.6 g (86%) of 12 as a foam after azeotroping with EtOH. The foam was used without further characterization in the hydrolysis reaction.

Provenance & Evidence