Sodium Hydroxide → HCID 23704038, compound

HRID 904225Notes

Reaction equation

HRID 904225 reaction equation
[OH-].[Na+:2].[CH3:3][C:4]1[CH:8]=[CH:7][S:6][C:5]=1[C:9]1[CH:14]=[CH:13][C:12]([CH:15]([CH3:19])[C:16]([OH:18])=[O:17])=[CH:11][CH:10]=1>>[CH3:3][C:4]1[CH:8]=[CH:7][S:6][C:5]=1[C:9]1[CH:10]=[CH:11][C:12]([CH:15]([CH3:19])[C:16]([O-:18])=[O:17])=[CH:13][CH:14]=1.[Na+:2]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 12769847HCID 12769847, compound

Product 1

HCID 23704038HCID 23704038, compound

Procedure

To 19.5 ml of 1 N sodium hydroxide solution was added 4.9 g (0.02 mole) of 2-[4-(3-methyl-2-thienyl)phenyl]propionic acid. After stirring for 30 minutes, the insoluble substance was removed by extraction with 20 ml of chloroform. The aqueous layer was concentrated under reduced pressure with heating. The residue was recrystallized from a toluene-water-dioxane mixture to obtain dihydrate of sodium 2-[4-(3-methyl-2-thienyl)phenyl]propionate having melting point of 206°-207° C.

Workup

  1. customthe insoluble substance was removed by extraction with 20 ml of chloroform
  2. concentrationThe aqueous layer was concentrated under reduced pressure
  3. temperaturewith heating
  4. customThe residue was recrystallized from a toluene-water-dioxane mixture

Sources & evidence

ORD record
ord-0314160fc05b4d97a451f6766eaa731f
Source dataset
uspto-grants-1980_10
Patent number
US04230719

Reaction notes

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