HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexamethylphosphoramide → 4-(15-Carbomethoxypentadecylamino)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexamethylphosphoramide | HCID 12679 | — |
| Reactant | 4-Aminobenzonitrile | HCID 13396 | — |
| Reactant | Methyl 16-bromohexadecanoate | HCID 2736822 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(15-Carbomethoxypentadecylamino)benzonitrile | HCID 21163376 | — |
Reaction Steps
A solution of 12 g. of 4-aminobenzonitrile and 15 g. of methyl 16-bromohexadecanoate in 200 ml. of hexamethylphosphoramide is heated at 120° for 22 hours, allowed to cool, and diluted with water. The mixture is chilled and the precipitate which forms is collected, dried, and recystallized from etherhexane to yield 4-(15-carbomethoxypentadecylamino)benzonitrile as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04230628 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-0d679bfe806d48cea6493aab62fff4f6 |
| Source note | uspto-grants-1980_10 |