HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → p-(15-Carbomethoxypentadecylamino)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Aminobenzoic Acid | HCID 978 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Methyl 16-bromohexadecanoate | HCID 2736822 | — |
| Solvent | Hexamethylphosphoramide | HCID 12679 | — |
| Product | p-(15-Carbomethoxypentadecylamino)benzoic acid | HCID 12898273 | — |
Reaction Steps
A mixture of 1.37 g. of 4-aminobenzoic acid, 3.50 g. of methyl 16-bromohexadecanoate, 2.12 g. of sodium carbonate and 140 ml. of hexamethylphosphoramide is stirred at 120° C. for 18 hours, allowed to cool, and poured into dilute hydrochloric acid. The precipitate is collected by filtration, dried, and crystallized from acetonitrile to yield 4-(15-carbomethoxypentadecylamino)benzoic acid as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04230628 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-4b2fefadca474afbb4e4c26af5de7bf0 |
| Source note | uspto-grants-1980_10 |