HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexamethylphosphoramide → 2,3-Dihydroxypropyl 4-(15-carbomethoxypentadecylamino)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexamethylphosphoramide | HCID 12679 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-Iodo-1,2-propanediol | HCID 92127 | — |
| Reactant | p-(15-Carbomethoxypentadecylamino)benzoic acid | HCID 12898273 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2,3-Dihydroxypropyl 4-(15-carbomethoxypentadecylamino)benzoate | HCID 21163245 | — |
Reaction Steps
A solution of 7.34 g. of 4-(15-carbomethoxypentadecylamino)benzoic acid, 4.80 g. of 25% aqueous sodium hydroxide, and 12.6 g. of 3-iodo-1,2-propanediol in 50 ml. of hexamethylphosphoramide is stirred for 24 hours at ambient temperature, diluted with 100 ml. of ether and stirred for 5 days at ambient temperature. The mixture is treated with water and extracted with ether. The dried extracts are evaporated to yield 2,3-dihydroxypropyl 4-(15-carbomethoxypentadecylamino)benzoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04230628 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-528112f10d68462b989291ea5f4a8a6c |
| Source note | uspto-grants-1980_10 |