Sodium Hydroxide → HCID 21163381, compound

HRID 904261Notes

Reaction equation

HRID 904261 reaction equation
[C:1]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21]1[CH:35]=[CH:34][C:24]([C:25]([NH:27][CH2:28][C:29]([O:31]CC)=[O:30])=[O:26])=[CH:23][CH:22]=1)([O:3][CH3:4])=[O:2].[OH-].[Na+]>C(O)C>[C:1]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21]1[CH:22]=[CH:23][C:24]([C:25]([NH:27][CH2:28][C:29]([OH:31])=[O:30])=[O:26])=[CH:34][CH:35]=1)([O:3][CH3:4])=[O:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 21163283HCID 21163283, compound

Product 1

HCID 21163381HCID 21163381, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 26.4 g. of ethyl N-[4-(15-carbomethoxypentadecylamino)benzoyl]glycinate, 110 ml. of 1 N sodium hydroxide solution; and 100 ml. of ethanol is stirred at ambient temperature for 2 hours and then partially evaporated. The aqueous solution is washed with diethyl ether, acidified with 6 N hydrochloric acid, and filtered. The white solid is dried in vacuo and recrystallized from acetone to yield the product.

Workup

  1. additionA mixture of 26.4 g
  2. custompartially evaporated
  3. washThe aqueous solution is washed with diethyl ether
  4. filtrationfiltered
  5. customThe white solid is dried in vacuo
  6. customrecrystallized from acetone
  7. customto yield the product

Sources & evidence

ORD record
ord-9876028036c145d7a5539b34d0b3ffdb
Source dataset
uspto-grants-1980_10
Patent number
US04230628

Reaction notes

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