Fumaric Acid → HCID 23333696, compound

HRID 904267Notes

Reaction equation

HRID 904267 reaction equation
Cl.[C:2]([NH:5][C:6]1[CH:30]=[CH:29][C:9]([NH:10][CH:11]2[CH2:20][CH:19]3[N:14]([CH2:15][CH2:16][C:17]4[CH:24]=[C:23]([O:25][CH3:26])[C:22]([O:27][CH3:28])=[CH:21][C:18]=43)[CH2:13][CH2:12]2)=[CH:8][CH:7]=1)(=[O:4])[CH3:3].[C:31]([OH:38])(=[O:37])/[CH:32]=[CH:33]/[C:34]([OH:36])=[O:35]>C(O)C>[C:31]([OH:38])(=[O:37])/[CH:32]=[CH:33]/[C:34]([OH:36])=[O:35].[C:2]([NH:5][C:6]1[CH:7]=[CH:8][C:9]([NH:10][CH:11]2[CH2:20][CH:19]3[N:14]([CH2:15][CH2:16][C:17]4[CH:24]=[C:23]([O:25][CH3:26])[C:22]([O:27][CH3:28])=[CH:21][C:18]=43)[CH2:13][CH2:12]2)=[CH:29][CH:30]=1)(=[O:4])[CH3:3]

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 23333698HCID 23333698, compound

Product 1

HCID 23333696HCID 23333696, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The free base of the compound prepared in Example II (TR-3605) in the amount of 1 g and 0.6 g of fumaric acid were dissolved in 75 ml of absolute ethanol. The solution was heated to boiled and allowed to cool whereupon the salt was collected and recrystallized from absolute ethanol to yield 1 g of the desired product m.p. (decomposed at 221°-2°).

Workup

  1. temperatureThe solution was heated
  2. temperatureto cool whereupon the salt
  3. customwas collected
  4. customrecrystallized from absolute ethanol

Sources & evidence

ORD record
ord-73d57fd4fd144fe2903e4638e4d0a449
Source dataset
uspto-grants-1980_10
Patent number
US04230710

Reaction notes

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