1-(2-Chloroethyl)pyrrolidine → HCID 23334040, compound

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Reaction Steps

In accordance with Example 1, 10 g. (0.042 mol) of 3-phenyl-4-hydroxy-coumarin are caused to react with 9.3 g. (0.055 mol) of 2-pyrrolidino-1-chlorethane. After evaporation of the methyl isobutyl ketone, the pasty residue is taken up under heat in 150 ml. of a 5% solution of sodium bicarbonate, this being followed by cooling and extraction with chloroform. The substance obtained is dried over Na2SO4 and the chloroform is evaporated under vacuum. A brown oil is obtained. Weight 6.5 g.; yield 46% (theoretical yield 14.1 g.).

Provenance & Evidence