HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Chloroethyl)morpholine → 8-Methoxy-4-(2'-morpholinoethoxy)-3-phenyl-coumarin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Chloroethyl)morpholine | HCID 76727 | — |
| Reactant | 8-Methoxy-4-hydroxy-3-phenylcoumarin | HCID 54721332 | — |
| Product | 8-Methoxy-4-(2'-morpholinoethoxy)-3-phenyl-coumarin | HCID 23334070 | 74% |
Reaction Steps
This compound is prepared according to the method of Example 8 from 45.6 g. (0.17 mol) of 3-phenyl-4-hydroxy-8-methoxy-coumarin and 30.5 g. (0.24 mol) of 2-morpholino-1-chlorethane. After recrystallisation from isopropanol, 48 g. are isolated; M.P. 90°-91° C. Yield 74% (theoretical yield 65.0 g.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04230850 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-60732d1f90384e999de23be4b8813069 |
| Source note | uspto-grants-1980_10 |