HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 4,6-Dihydroxy-3-phenyl-coumarin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 4-Hydroxy-6-methoxy-3-phenyl-2H-1-benzopyran-2-one | HCID 54705896 | — |
| Reactant | Dioxane diisopropyl ether | HCID 67198123 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4,6-Dihydroxy-3-phenyl-coumarin | HCID 54721335 | 33.7% |
Reaction Steps
Prepared in the manner described in Example 25, Stage A, from 37.6 g. (0.14 mol) of 6-methoxy-4-hydroxy-3-phenyl-coumarin, 375 ml. of glacial acetic acid, 750 ml. of 62% hydrobromic acid and 375 ml. of acetic anhydride. Weight 12.2 g.; yield 33.7% (theoretical yield 35.6 g.); M.P. 261°-263° C. (dioxane-diisopropyl ether: 50-50).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04230850 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-76a01896133b4ab4885dc3f97abfa7bd |
| Source note | uspto-grants-1980_10 |