Potassium Iodide → HCID 23334095, compound

Participants

Reaction Conditions

Reaction Steps

76.3 g. (0.3 mol) of 4,5-dihydroxy-3-phenyl-coumarin (Example 23a), 25.2 g. (0.3 mol) of sodium bicarbonate, 3 g. of potassium iodide and 800 ml. of methyl isobutyl ketone are brought over one hour to 80° C. The mixture is then cooled to 60° C., whereafter 48.4 g. (0.324 mol) of 2-morpholino-1-chlorethane are added dropwise and the temperature is brought over 8 hours to 100° C. It is then left at room temperature for one night and filtered. The precipitate obtained is taken up in 1 liter of chloroform. The light, insoluble substance obtained is filtered and the chloroform is evaporated under vacuum. The residue obtained is recrystallised from 700 ml. of methyl isobutyl ketone. 50 g. of a white product are isolated. M.P. 206° C.; yield 44.5% (theoretical yield 110.2 g.).

Provenance & Evidence