Potassium Iodide → HCID 23334032, compound

Participants

Reaction Steps

18.4 g. (0.05 mol) of 4-(2'-morpholinoethoxy)-5-hydroxy-3-phenyl coumarin (Example 30), 9.7 g. (0.07 mol) of potassium carbonate, 0.5 g. of potassium iodide and 250 ml. of methyl isobutyl ketone are brought over one hour to 80° C. The temperature is then brought to 60° C. and 7.6 g. (0.06 mol) of freshly distilled dimethyl sulphate are added dropwise in 20 minutes. Refluxing takes place for 8 hours and, after cooling, filtering is carried out. The filtrate is evaporated under vacuum and then, after washing with sodium bicarbonate and then water, and extraction with chloroform, there are obtained, after evaporation, 4.8 g. of an oil which cannot be crystallised. Yield 25.2% (theoretical yield 19.1 g.).

Provenance & Evidence