4-(2-Chloroethyl)morpholine → HCID 23334065, compound

HRID 904307Notes

Reaction equation

HRID 904307 reaction equation
[C:1]1([C:7]2[C:8](=[O:19])[O:9][C:10]3[C:15]([C:16]=2[OH:17])=[CH:14][CH:13]=[C:12]([OH:18])[CH:11]=3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[O:20]1[CH2:25][CH2:24][N:23]([CH2:26][CH2:27]Cl)[CH2:22][CH2:21]1>>[O:20]1[CH2:25][CH2:24][N:23]([CH2:26][CH2:27][O:17][C:16]2[C:15]3[C:10](=[CH:11][C:12]([OH:18])=[CH:13][CH:14]=3)[O:9][C:8](=[O:19])[C:7]=2[C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 767274-(2-Chloroethyl)morpholineHCID 54689806Coumarin, 4,7-dihydroxy-3-phenyl-

Product 1

HCID 23334065HCID 23334065, compoundYield 77.6%

Procedure

Following the method of Example 30, 30.5 g. (0.12 mol) of 3-phenyl-4,7-dihydroxy-coumarin are treated with 19.5 g. (0.13 mol) of 2-morpholino-1-chloroethane. 34 g. of an oil are obtained, which cannot be crystallised. Yield 77.6% (theoretical yield 44.7 g.).

Workup

  1. customof an oil are obtained
  2. customwhich cannot be crystallised

Sources & evidence

ORD record
ord-4072ad36423f44b7b86a73b818790940
Source dataset
uspto-grants-1980_10
Patent number
US04230850

Reaction notes

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