HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Chloroethyl)morpholine → 8-Methoxy-4-(2'-morpholinoethoxy)-3-phenyl-coumarin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Chloroethyl)morpholine | HCID 76727 | — |
| Reactant | 8-Methoxy-4-hydroxy-3-phenylcoumarin | HCID 54721332 | — |
| Product | 8-Methoxy-4-(2'-morpholinoethoxy)-3-phenyl-coumarin | HCID 23334070 | 76% |
Reaction Steps
As in Example 8, 45.6 g. (0.17 mol) of 8-methoxy-4-hydroxy-3-phenyl-coumarin are treated with 30.5 g. (0.20 mol) of 2-morpholino-1-chlorethane. After evaporation of the chloroform and recrystallisation from isopropanol, 48 g. of a beige-coloured solid are obtained. M.P. 90°-91° C.; yield 76% (theoretical yield 63 g.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04230850 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-38183cca69984b55a5fd6844e6e176e0 |
| Source note | uspto-grants-1980_10 |