HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Chloroethyl)morpholine → 8-Hydroxy-4-(2'-morpholinoethoxy)-3-phenyl-coumarin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Chloroethyl)morpholine | HCID 76727 | — |
| Reactant | 3-Phenyl-4,8-dihydroxy-coumarin | HCID 54721333 | — |
| Product | 8-Hydroxy-4-(2'-morpholinoethoxy)-3-phenyl-coumarin | HCID 23334033 | 60.2% |
Reaction Steps
Prepared as described in Example 30 from 45.9 g. (0.18 mol) of 3-phenyl-4,8-dihydroxy-coumarin and 31.5 g. (0.21 mol) of 2-morpholino-1-chloroethane. After recrystallisation from ethane, 39.8 g. of a white substance are obtained; M.P. 190°-191° C. Yield 60.2% (theoretical yield 66 g.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04230850 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-52b8dbae60f74fa48044aacda589d442 |
| Source note | uspto-grants-1980_10 |