Triethylamine → HCID 86737297, compound

Participants

Reaction Steps

14.2 g. (0.034 mol) of 4-(3'-morpholino-2'-hydroxypropoxy)-3-phenyl-coumarin hydrochloride (Example 32) are placed in 130 ml. of chloroform containing 3.4 g. (0.034 mol) of triethylamine. A solution of 7.83 g. (0.034 mol) of 3,4,5-trimethoxy-benzoyl chloride in 20 ml. of chloroform are then added in 21/2 hours. The mixture is then brought over 2 hours to 40°-50° C. Cooling takes place, the insoluble substance is filtered off, the filtrate is washed with a sodium bicarbonate solution and dried over sodium sulphate. The solvent is evaporated under vacuum and there are obtained 14.3 g. of an oil which cannot be crystallised. Yield 73.4% (theoretical yield 19.5 g.).

Provenance & Evidence