HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Chloroethyl)morpholine → 4-(2'-Morpholinoethoxy)-3-phenyl-6-tert.-butyl-5,6,7,8-tetrahydro-coumarin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Chloroethyl)morpholine | HCID 76727 | — |
| Reactant | 4-Hydroxy-3-phenyl-6-tert.butyl-5,6,7,8-tetrahydro-coumarin | HCID 57229129 | — |
| Product | 4-(2'-Morpholinoethoxy)-3-phenyl-6-tert.-butyl-5,6,7,8-tetrahydro-coumarin | HCID 23334094 | 84.6% |
Reaction Steps
Obtained according to Example 14, Stage B, by treating 14.2 g. (0.05 mol) of 4-hydroxy-3-phenyl-6-tert.butyl-5,6,7,8-tetrahydro-coumarin with 9.7 g. (0.065 mol) of 2-morpholino-1-chlorethane. After evaporation of the chloroform, 17 g. of an oil are obtained, which cannot be crystallised. Yield 84.6% (theoretical yield 20.35 g.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04230850 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-3e673551f67c4932bef4cee220555d22 |
| Source note | uspto-grants-1980_10 |