4-(2,3-Epoxypropyl)morpholine → 4-(3'-Morpholino-2'-hydroxypropoxy)-3-phenyl-5,6,7,8-tetrahydrocoumarin

関与物質

反応手順

A solution of 4-hydroxy-3-phenyl-5,6,7,8-tetrahydrocoumarin and 3-morpholino-1,2-epoxypropane in methyl isobutyl ketone is brought under reflux for 8 hours. Evaporation is carried out under vacuum and the residue is taken up by a 5% solution of sodium bicarbonate and kept for 15 minutes at reflux. After cooling, extraction is carried out with chloroform, drying takes place on sodium sulphate and the chloroform is evaporated. An oil is obtained which cannot be crystallised. Yield 77%.

情報源と証拠