Hydrochloric Acid → 2-Thiophenecarboxylic acid, 3-(chlorosulfonyl)-, methyl ester

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Reaction Steps

48 g (0.196 mol) of the obtained 3-chlorosulphonylthiophene-2-carboxylic acid chloride are dissolved in 500 ml of absolute chloroform, 9.6 g (0.3 mol) of absolute methanol are added and the mixture is heated to reflux for 3 hours [until no more hydrogen chloride evolution]. The mixture is evaporated to dryness in vacuo and the residue allowed to crystallise. There is obtained pure 3-chlorosulphonylthiophene-2-carboxylic acid methyl ester.

Provenance & Evidence