Methyl Isocyanate → N-Methyl-N'-[2-(2-pyrazinylmethylamino)ethyl]urea

HRID 904398Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[CH2:7][NH:8][CH2:9][CH2:10][NH2:11].[CH3:12][N:13]=[C:14]=[O:15]>>[CH3:12][NH:13][C:14]([NH:11][CH2:10][CH2:9][NH:8][CH2:7][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][N:1]=1)=[O:15]

Participants

Reactant 2

HCID 12228Methyl Isocyanate

HCID 13910894N-(pyrazinylmethyl)ethylenediamine

Product 1

HCID 20557893N-Methyl-N'-[2-(2-pyrazinylmethylamino)ethyl]urea

Procedure

Reacting N-(2-pyrazinylmethyl)ethylenediamine with methyl isocyanate by the procedure of Example 24, then concentrating and separating the residue by column chromatography gives the title compound.

Workup

concentrationconcentrating
customseparating the residue by column chromatography

Sources & evidence

ORD record: ord-40ce651365b5480790db70abd576f158
Source dataset: uspto-grants-1980_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04230865

Reaction notes

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