Methyl Isocyanate → N-Methyl-N'-[2-(3-pyridazinylmethylamino)ethyl]urea

HRID 904402Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH:8][CH2:9][CH2:10][NH2:11])[N:2]=1.[CH3:12][N:13]=[C:14]=[O:15]>>[CH3:12][NH:13][C:14]([NH:11][CH2:10][CH2:9][NH:8][CH2:7][C:3]1[N:2]=[N:1][CH:6]=[CH:5][CH:4]=1)=[O:15]

Participants

Reactant 2

HCID 12228Methyl Isocyanate

HCID 21698444N-(3-pyridazinylmethyl)ethylenediamine

Product 1

HCID 20557601N-Methyl-N'-[2-(3-pyridazinylmethylamino)ethyl]urea

Procedure

Reacting N-(3-pyridazinylmethyl)ethylenediamine with methyl isocyanate by the procedure of Example 24, then concentrating and separating the residue by column chromatography gives the title compound.

Workup

concentrationconcentrating
customseparating the residue by column chromatography

Sources & evidence

ORD record: ord-14eae843b7d34e6a988127bd464f6eae
Source dataset: uspto-grants-1980_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04230865

Reaction notes

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