Methyl Isocyanate → N-Methyl-N'-[2-(2-benzimidazolylmethylthio)ethyl]urea

HRID 904436Notes

Reaction equation

[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[NH:7][C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=2[N:10]=1.[CH3:15][N:16]=[C:17]=[O:18]>>[CH3:15][NH:16][C:17]([NH:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[NH:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[N:7]=1)=[O:18]

Participants

Reactant 2

HCID 12228Methyl Isocyanate

HCID 129234202-[(2-Aminoethyl)thiomethyl]benzimidazole

Product 1

HCID 20557872N-Methyl-N'-[2-(2-benzimidazolylmethylthio)ethyl]urea

Procedure

By the procedure of Example 24, 2-[(2-aminoethyl)thiomethyl]benzimidazole is reacted with methyl isocyanate to give the title compound.

Sources & evidence

ORD record: ord-9397d73a6c714e4a9ce80a348174bf0b
Source dataset: uspto-grants-1980_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04230865

Reaction notes

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