6-Chloronicotinamide → HCID 12862364, compound

HRID 904527Notes

Reaction equation

HRID 904527 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]([NH2:10])=[O:9])=[CH:4][CH:3]=1.[NH2:11][C:12]1[S:13][C:14]([CH2:22][CH2:23][CH3:24])=[CH:15][C:16]=1[C:17](OCC)=[O:18]>>[O:18]=[C:17]1[N:7]2[CH:6]=[C:5]([C:8]([NH2:10])=[O:9])[CH:4]=[CH:3][C:2]2=[N:11][C:12]2[S:13][C:14]([CH2:22][CH2:23][CH3:24])=[CH:15][C:16]1=2

Participants

3

Reactant 2

HCID 804566-ChloronicotinamideHCID 3399457ethyl 2-amino-5-propylthiophene-3-carboxylate

Product 1

HCID 12862364HCID 12862364, compoundYield 312%

Procedure

From 4.6 g (0.0029 mol) of 6-chloro-3-pyridinecarboxamide (Aldrich Chemical Company) and 8.6 g (0.040 mol) of 2-amino-5-propyl-3-thiophenecarboxylic acid, ethyl ester, following the procedure of Example 22 there is obtained 2.6 g of 4-oxo-2-propyl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxamide; mp 260°-264° C. after recrystallization from pyridine.

Sources & evidence

ORD record
ord-197c1d34f2da4b479ed74cd0c7286040
Source dataset
uspto-grants-1980_10
Patent number
US04230707

Reaction notes

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