Ethyl 2-amino-4,5-dimethyl3-thenoate → HCID 12862368, compound

HRID 904530Notes

Reaction equation

HRID 904530 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]([NH2:10])=[O:9])=[CH:4][CH:3]=1.[NH2:11][C:12]1[S:13][C:14]([CH3:23])=[C:15]([CH3:22])[C:16]=1[C:17](OCC)=[O:18]>>[CH3:23][C:14]1[S:13][C:12]2[N:11]=[C:2]3[CH:3]=[CH:4][C:5]([C:8]([NH2:10])=[O:9])=[CH:6][N:7]3[C:17](=[O:18])[C:16]=2[C:15]=1[CH3:22]

Participants

3

Reactant 2

HCID 78536Ethyl 2-amino-4,5-dimethyl3-thenoateHCID 804566-Chloronicotinamide

Product 1

HCID 12862368HCID 12862368, compound

Procedure

From 6.0 g (0.038 mol) of 6-chloro-3-pyridinecarboxamide (Aldrich Chemical Company) and 8.0 g (0.040 mol) of 2-amino-4,5-dimethyl-3-thiophenecarboxylic acid, ethyl ester (Chemische Berichte, Vol. 99, pages 94-100, 1966), following the procedure of Example 22, there is obtained 2,3-dimethyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxamide; mp 361°-363° C. after recrystallization from pyridine.

Sources & evidence

ORD record
ord-08146c1c511d42d8942caa9c24c1404a
Source dataset
uspto-grants-1980_10
Patent number
US04230707

Reaction notes

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