HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloronicotinamide → 2-methyl-10-oxo-10H-pyrido[1,2-a]thieno[3,2-d]pyrimidine-7-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloronicotinamide | HCID 80456 | — |
| Reactant | 3-Amino-5-methyl-thiophene-2-carboxylic acid methyl ester | HCID 818952 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 2-methyl-10-oxo-10H-pyrido[1,2-a]thieno[3,2-d]pyrimidine-7-carboxamide | HCID 12953054 | 14.6% |
Reaction Steps
A mixture of 2.7 g (0.0158 mol) of 3-amino-5-methyl-2-thiophenecarboxylic acid, methyl ester (German Patent 1055007, April 16, 1959) and 2.5 g (0.0158 mol) of 6-chloro-3-pyridinecarboxamide (Aldrich Chemical Company) is heated in an oil bath at 180°-190° C. for one hour. The mixture is cooled and then suspended in hot chloroform and filtered to give 0.6 g of 2-methyl-10-oxo-10H-pyrido[1,2-a]thieno[3,2-d]pyrimidine-7-carboxamide; mp 375°-377° C. after recrystallization from pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04230707 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-ba9ba352267a441fbb588e49438ae9c8 |
| Source note | uspto-grants-1980_10 |