Ethyl orthoformate → HCID 178423414, compound

HRID 904638Notes

Reaction equation

HRID 904638 reaction equation
[NH2:1][C:2]1[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:3]=1[C:4]([NH:6][C:7]1[NH:11][N:10]=[N:9][N:8]=1)=[O:5].[CH2:17](OC(OCC)OCC)C>>[CH3:16][C:13]1[CH:12]=[C:3]2[C:2](=[CH:15][CH:14]=1)[N:1]=[CH:17][N:6]([C:7]1[NH:11][N:10]=[N:9][N:8]=1)[C:4]2=[O:5]

Participants

3

Reactant 2

HCID 31214Ethyl orthoformateHCID 178426476HCID 178426476, compound

Product 1

HCID 178423414HCID 178423414, compound

Procedure

2-Amino-5-methyl-N-(1H-tetrazol-5-yl)benzamide in an excess of triethoxymethane was refluxed for 60 hours to give 6-methyl-3-(1H-tetrazol-5-yl)-4(3H)-quinazolinone melting at about 285°-286° C. after recrystallization from a mixture of dimethylsulfoxide and water.

Sources & evidence

ORD record
ord-c08c9f16b09847c495d4908db9100aa8
Source dataset
uspto-grants-1983_12
Patent number
US04419357

Reaction notes

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