Ethyl orthoformate → HCID 178515097, compound

HRID 904640Notes

Reaction equation

HRID 904640 reaction equation
[NH2:1][C:2]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][C:3]=1[C:4]([NH:6][C:7]1[NH:11][N:10]=[N:9][N:8]=1)=[O:5].[CH2:17](OC(OCC)OCC)C>>[Cl:16][C:13]1[CH:12]=[C:3]2[C:2](=[CH:15][CH:14]=1)[N:1]=[CH:17][N:6]([C:7]1[NH:11][N:10]=[N:9][N:8]=1)[C:4]2=[O:5]

Participants

3

Reactant 2

HCID 31214Ethyl orthoformateHCID 178507590HCID 178507590, compound

Product 1

HCID 178515097HCID 178515097, compound

Procedure

A suspension of 2.73 g of 2-amino-5-chloro-N-(1H-tetrazol-5-yl)benzamide in 9 ml of triethoxymethane was refluxed for 4.5 hours to give 6-chloro-3-(1H-tetrazol-5-yl)-4(3H)-quinazolinone melting at about 241° C. (dec).

Workup

  1. temperaturewas refluxed for 4.5 hours

Sources & evidence

ORD record
ord-d9c4eba91e8d4a02b77d3ae6c2534964
Source dataset
uspto-grants-1983_12
Patent number
US04419357

Reaction notes

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