Ethyl orthoformate → HCID 178514850, compound

HRID 904642Notes

Reaction equation

HRID 904642 reaction equation
[NH2:1][C:2]1[CH:15]=[C:14]2[O:16][CH2:17][O:18][C:13]2=[CH:12][C:3]=1[C:4]([NH:6][C:7]1[NH:11][N:10]=[N:9][N:8]=1)=[O:5].[CH2:19](OC(OCC)OCC)C>COCCO>[CH2:17]1[O:16][C:14]2[CH:15]=[C:2]3[C:3]([C:4](=[O:5])[N:6]([C:7]4[NH:8][N:9]=[N:10][N:11]=4)[CH:19]=[N:1]3)=[CH:12][C:13]=2[O:18]1

Participants

4

Reactant 2

HCID 31214Ethyl orthoformateHCID 178507192HCID 178507192, compound

Product 1

HCID 178514850HCID 178514850, compound

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

A slurry of 11.6 g of 2-amino-4,5-methylenedioxy-N-(1H-tetrazol-5-yl)benzamide and 25 g of triethoxymethane in 150 ml of 2-methoxyethanol was heated at reflux for 1 hour. A complete solution was not obtained at any time but the final mixture was filtered and the separated solid was air dried and recrystallized from a mixture of dimethylformamide and methanol to give 6,7-methylenedioxy-3-(1H-tetrazol-5-yl)-4(3H)-quinazolinone melting at about 280° C. (dec).

Workup

  1. temperatureat reflux for 1 hour
  2. customA complete solution was not obtained at any time
  3. filtrationthe final mixture was filtered
  4. customdried
  5. customrecrystallized from a mixture of dimethylformamide and methanol

Sources & evidence

ORD record
ord-c1c468e4583447bb9995795fdb12541d
Source dataset
uspto-grants-1983_12
Patent number
US04419357

Reaction notes

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